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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

This way you can tell everyone to shut up and get out so you can go to your "mind palace".
Released in 2013, The Bling Ring is a satirical crime drama that chronicles the adventures of Hollywood Hills high schoolers who burgle the homes of local celebrities. The teens break into homes of icons like Megan Fox and Paris Hilton, stealing cash, clothes, handbags, and jewelry to help them emulate the excessive lifestyles they admire in magazines. The students are eventually caught and sent to jail after posting pictures of their hauls on social media.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

[si'lebriti]
《危险!》(Jeopardy!):这个游戏节目今年已播出50年(1964年3月30日首播),它证明自己不仅能难住观众,而且能令他们感到意外。不仅是因为主持人亚历克斯·特里贝克(Alex Trebek)留起了胡子(之前13年他都是把胡子剃得干干净净),而且是因为仍有些选手表明自己能刺激观众。今年刺激观众的是亚瑟·朱(Arthur Chu),他采用闪电战式的答题方式,在网上引起一片哗然。他的策略令人兴奋,当然也很奏效:他在锦标赛中夺得第二名(友善的本·因格拉姆[Ben Ingram]最后得了第一)。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

国考报名将于本月24日截止,而考试将于11月27日在中国各大城市举行。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

她是头号权势女性:过去10年里,德国总理默克尔八度上榜——其中七次都荣登榜首。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 快刷时代,涂企如何“玩转”营销
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Hurricane Harvey
La La Land producer Jordan Horowitz returned to the microphone after being told about the mix up and said 'Moonlight won Best Picture' and insisting that 'this is not a joke'.
成长的故事:现代的巴黎郊区与20世纪70年代的旧金山,这两部影片以残酷的城市和无尽的热情,把成长为女人的可怕惊险之路变得戏剧化。
According to Putin's most recent income declaration, he earned roughly 8.9 million rubles ($137,000) in 2015.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

The 2017 grads of Tsinghua University earn an average salary of 9,065 yuan per month, according to the survey released by xinchou.cn, an internet salary survey and report provider.
只有公民,而他们的选择不仅可能、而且必然会改变。
北韩已经警告过Park,如果电影穿越边境,将会要他"以命偿罪"。
新上榜学校中排名最高的是巴黎第九大学(Université Paris-Dauphine),排在第57位。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

除了这些理论之外,还有传统经济学家用来误导美国的坏的统计数据:最恶劣的是GDP,它在衡量美国长期增长的时候是一个狭窄的、误导人的指标。其次,我们对短期数据(每日收盘情况、季度业绩、年度回报等)的执迷正在阻碍美国的长远增长。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

促进消费稳定增长。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Olive Yang
n. 经营方法,行为态度

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

n. 好客,殷勤,酒店管理
Banks just cannot afford to keep up. At Goldman Sachs, for example, net revenues have dropped about a third since 2009, beaten down by structural shifts in trading and new rules crimping risk-taking. The bank tries to keep its pay ratio stable, so that means smaller total packages for the typical employee.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 定制家具或将成未来消费热点
Open Access Review Article

Diagnostic technologies for COVID-19: a review

父母获得孩子尊重的7种方法
最后西蒙点评:“你们在唱的时候眼睛里透露出坚定,唱得相当投入,第一次我听到你们唱这首歌的时候我觉得很惊艳,而这一次提高了不少,更上了一个台阶。”

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 建筑卫生陶瓷产业急需转型升级
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

由于电影业采取了更为市场化的改革措施,中国的票房总额在过去几十年里从10亿元人民币增长到了400亿元人民币。
Emissions have been falling gradually in recent years in most of the developed countries, in part because of economic weakness but also because of strengthening climate policies. Emissions in the 28-nation European Union fell 1.8 percent in 2013, despite increases in coal consumption in a few countries, including Germany and Poland. Emissions decreased sharply in Britain, Italy and Spain.
户外空间:从这座露台往下走几步就是一座带有草坪和喷泉、围着围墙的花园。这处房产面积0.10英亩(约405平方米)。
埃尔·南德斯

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
From the themed collection: 资源整合成家居行业年度关键词
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

尤吉利时机恰当和思虑周密的举动应该能扭转猛龙下滑的颓势。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
From the themed collection: “旅游+区块链”未来市场广阔
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Metals cases made up a record 46 per cent of the 233 anti-dumping actions brought worldwide in 2015, with the steel industry accounting for almost all of the metals complaints.
但是,是什么推动了乐观或悲观情绪呢?库迪斯与巴塞罗那庞培法布拉大学(Universitat Pompeu Fabra)的汉斯-乔亚吉姆o沃斯发现了一些令人意外的答案。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Ultimately I expect these new leaders to start selecting from a broader pool of candidates and appoint direct reports from more varied backgrounds, defying those who use current imbalances to extrapolate gloomily that leadership parity between men and women is still decades off.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Man-made climate change is the main culprit for warming that was leading the world into “uncharted territory”, said Peter Stott, head of climate monitoring and attribution at the UK Met Office’s Hadley Centre for climate research, which released separate findings confirming the US analysis.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
From the themed collection: 限购加码楼市调控鼓点渐强
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

The reality turned out to be tougher than he imagined. “I saw it as a two-year opportunity,” says Mr Ravenscroft. “The grinding reality is that it’s a slog.” Moreover, his mentor worked at Lehman Brothers, the bank that collapsed in 2008. “It wasn’t quite as long a mentoring relationship as I’d hoped,” he laughs.
当然,2016年不同寻常的政治局势有着复杂的轮廓。在英国,来自南亚的移民投票大力支持退出欧盟,表示希望限制欧洲移民,以便为更多来自亚洲的移民开放空间。在美国,对政治现状的不满与脱离助长了特朗普的崛起势头。
Actress in a Comedy Series: Julia Louis-Dreyfus, “Veep”
单词previous 联想记忆:

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

James Bond Themes Honorable Mention: "We Have All The Time in the World" by Louis Armstrong
赫梅尔说,“如果发达经济体的原油需求增加,再加上新兴经济体需求的增多,我认为市场供应将趋紧。”这意味着油价走势图上可能会再度出现多个高峰。
I once had an advisor that said to me when I expressed fear of a difficult class, "Do you want to get an education or not?"
布雷克·格里芬的高中样子和现在相差不大。只要在高中版的格里芬上加一些头发,再增大他的肌肉,就变成了如今的格里芬。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

If you happen to be shy, sitting in the front row can be very uncomfortable at first, but I promise you, it's one of the best ways to pay attention to everything being taught. You can hear better. You can see everything on the board without having to crane your neck around the head in front of you.
Bringing harmony to Apple’s internal fiefdoms has not been easy. There is still “huge tension” inside Apple, according to one person who has worked with the company for many years. “That tension is something he uses to run the company but it can be dangerous.”

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
From the themed collection: 杭州新政:承租人子女可就近上学
Critical Review

The role of biosensors in the detection of emerging infectious diseases

One of Iese’s strengths is its academic rigour. The Barcelona school performs consistently highly across all aspects of customised programmes. It is ranked in the top five in 11 criteria out of 15. Iese is top for its international clients and the diversity of its faculty.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

相比之下,小型货车销量却开始走下坡路,其成交量仅为7.13万台,同比跌幅31%。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Over the next few years, large residential buildings will have to comply with Local Law 87, which requires them to audit energy usage and keep systems running at peak efficiency. Residential buildings are the city’s largest source of greenhouse gas emissions, accounting for 37 percent of the total. “The one hot-button topic is energy. How do buildings become more energy efficient?” said Dan Wurtzel, the president of FirstService Residential New York, which manages more than 500 properties. “If a third of your operating budget is related to energy and you can now reduce that cost, you can take pressure off the need for a maintenance increase.”
The 2017 rankings feature the top 60 pre-experience courses for students with little or no background in the industry and the top six post-experience programmes for professionals already working in the sector. Only a handful of schools offer post-experience courses.
On average, executive pay packets hit 7.09 million yuan in 2016, up 8% year-on-year, higher than the rate of China's GDP and per capita disposable incomes, which were 6.7% and 6.3% respectively.
梅瑟威对战麦克格雷戈的战斗

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

总排名76位的新加坡管理大学(Singapore Management University)李光前商学院(Lee Kong Chian School of Business)是首家进入这一排行榜的新加坡商学院。今年共7家亚洲商学院上榜。李光前商学院校友在亚洲商学院中最具国际流动性。他们在流动性指标方面排名第25,比在亚洲商学院中流动性排第二的台湾国立中山大学(National Sun Yat-Sen University)高57位。
Miley Cyrus
8. Smile every time EXCEPT when my team is losing.
spontaneous

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

transport
上周五,中国汽车制造协会宣布,1月份的乘用车销量达到220万台,比去年同期增长了9.3%,同时,新能源汽车的产量则激增了144%。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

‘Can’t fault, I was thinking “go on boys”,’ Alesha smiled.
饰演《哈利·波特》里赫敏一角的艾玛·沃特森在2015全球十大美女榜中居第五。这位英国演员、模特、社会活动积极分子在2015年“问男人”网站评选的“九十九位最杰出女性”中夺冠,并且在《时代》杂志全球最具影响力人物评选中列第26位。
单词retreat 联想记忆:
以下是2012年搞笑诺贝尔奖得奖名单,这些奖项被授予那些做出看起来愚蠢却又对世界有深度贡献的科学家、作家、和平缔造者们,或者用主办方《不可思议研究年报》的话来说就是奖励那些“乍看起来让人发笑,但是随后发人深省”的研究工作。我敢担保,这些发明绝对能使人们大笑!
There is a natural human tendency to idealize and whitewash days of yore, to cast them in the rosy glow of the mind’s eye.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

The Office for National Youth Campus Football said that China already had 13,381 "special football schools" as of 2016, and 69 counties are piloting programs for football in schools, the Xinhua News Agency reported.
Anna Faith Carlson, 18, became an online sensation when she posted a picture of her posing next to a cardboard cutout of Elsa a few months ago.
时间:2010-03-14 编辑:alex

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

谎言3:是的,这挺有道理的。说谎原因:方案二会让我显得毫无头绪。
菲律宾参议院一委员会就国内发生的法外处决事件举行了听证会,罗纳德?德拉罗萨(Ronald Dela Rosa)在会上表示,自7月1日杜特尔特就任总统后,有712人在警方缉毒行动中被杀,还有1067起死亡正被作为与毒品相关的自告奋勇者杀人案件在调查中。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

Tiger got to sleep, bird got to land;
1.无叶风扇
Iron ore imports fell 12.3 per cent by volume in October from the previous month and 4.9 per cent from the same month a year earlier while coal imports were down 21.4 per cent from September and 30.7 per cent from a year earlier, according to Chinese customs data.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

三线城市居民的经济压力和人际关系压力相对较小,且拥有更好的社会环境、自然环境和基础设施。
瑞士洛桑国际管理发展学院在针对所有在职管理人员的开放招生课程排行榜中拔得头筹,在针对企业客户的定制课程排行榜中攀升了两位,升至第二。西班牙Iese商学院在定制课程排行榜上继续保持榜首位置,在开放课程排行榜中仍位居第二。
他说:“国内需求增长太慢,而新增出口订单的增幅又放缓至5个月内的低点……我们依然预计(中国政府)会推出进一步货币和财政宽松举措,以抵消经济增长的下行风险。”

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Like many child stars, Maddie speaks of being old before her time.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

Truck wars: Awards aside, Ford’s aluminum pickup is hard to build and slow to sell, leaving an opening for Ram’s fast-rising 1500 while Nissan tries to forget the failure of its first full-size truck when it launches the second-generation Titan with the biggest of big rig styling. The industry’s biggest secret is revealed by veteran executive John Krafcik in Automotive News: In the

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Glazer surely took something, again, from Kubrick, especially in the scene in which his alien is born in some dimensionless otherworld. He took something from Nic Roeg and The Man Who Fell to Earth and a little, perhaps, from David Lynch – of which, more in a moment. But alongside the sci-fi exoticism he brought the grit and sinew of contemporary realism, calling to mind the work of film-makers like Ken Loach, or even Abbas Kiarostami and the opening of his The Taste of Cherry, in which a desperately unhappy man drives around the itinerant labour markets of Teheran looking for someone to help him. These fantastic alien forms are scuffed with ordinariness and even bathos. The scene in which the alien uncomprehendingly watches Tommy Cooper on television is a masterpiece of tonal suspense.
Wishing you all the blessings of a beautiful season.愿你拥有美丽的新年所有的祝福。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

The world is casting its eye on Brazil for hosting two of the most coveted sporting events — the 2014 FIFA World Cup and the Summer Olympics two years after. Except for watching exciting games and cheering for your favorite team and players, you can also take a trip to “the lungs of the earth”, the Amazon forest, to escape the crowds and embrace nature. Either way, Brazil is sure to leave you with an unforgettable memory.
After enjoying a weekend of football in Manchester, David Beckham quickly jetted across the Pond to New York last night to spend Valentine’s Day with his p
迅速崛起的“色情短信”服务商Snapchat与早期的社交媒体巨头Facebook具有令人不可思议的相似性。我们现在都知道扎克伯格早早就投下的赌注获得了多大的成功(更不必说他还彻底击败了卑劣的文克莱沃斯孪生兄弟)。那么,Snapchat能否拥有同样光明的未来?
飞速变化的效应

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

In an interview with Yicai magazine last week, the chairman of China Construction Bank pointed to the rising tide of non-performing loans as the biggest problem confronting China’s banks.
But national and racial identity were often conflated for the white majority. That identity felt to many white people like one of the most important pillars holding up their world — and now it seems under threat.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

“The employee submitted a message through the company web site.”
Wishing you all the happiness of the holiday season.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

40万美元对于他们来说可谓九牛一毛——2015年,希拉里和她的丈夫比尔?克林顿主要通过演讲和版税收入赚得了1060万美元,特朗普也声称自己赚得将近5600万美元。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

同样,学校暑假期间在普华永道的一个为期3周的实习职位让她有机会体验在一家专业服务公司的生活。她说:“我曾经以为自己参加不了(普华永道项目),因为我没有工作经验。”
“我们需要做市长希望大家做的事——建造更多住房,”纽约房地产委员会主席史蒂芬·斯皮诺拉(Steven Spinola)说,但是,“如果数据上不可行,如果收回来的租金低于建筑的维护成本,那你就不会这么做了。”
Chinese imports fell 18.8 per cent in October from the same month a year earlier, a slight improvement from the 20.4 per cent year-on-year fall in September. Sharply lower prices of oil and other commodities also helped scythe the bill.
卷铺走人的时候

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

不过,如果把10月份看做一个整体,则只有深圳房价真正出现了环比下滑。
排名:第三

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

这一问题也打击了中国在WTO框架内获得市场经济地位的努力。中国声称,在其加入WTO满15周年的今年12月,应当自动获得市场经济地位。如果中国获得了该地位,那么这可能影响美国等国对中国发起反倾销案的能力,因为这将使他们不能用替代国的价格进行比价。
In this Jan. 7, 1997, file photo, Steve Jobs, chief executive of Pixar, speaks at the MacWorld trade show in San Francisco.
6. Smart refrigerator

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

il不+legal合法的→不合法的
反对:纽约时和洛杉矶影评人协会都对该片无感。
献上节日的问候与祝福,愿你拥有一个充满生机和欢乐的新年。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

交通运输部新闻发言人徐成光通报称,未发现更多生命迹象,搜寻到生还者的希望"非常渺茫"。
在"踢脚舞"这集中,我们得以看到伊莱恩·薄伯那难以置信的滑稽舞步。简直难以想象没有她这么带感的放克舞蹈,《宋飞正传》会是什么样子。然而,令人震惊的是,那差点就成了现实。编剧之一斯派克·费雷斯滕知道,制作人拉里·戴维一定会反对这场舞戏,所以他只能等到戴维离开之后。当他的这场舞戏终于获得许可,却又遭到不少同事的强烈反对。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 个人车位共享“叫好不叫座”
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Scientists have long investigated stem cells' potential for growing hearts, and they reached a major milestone this year when they created heart tissue than can beat on its own.
我们要让权力不能任性,就得把那些不应该有的权力砍掉,有些涉及到部门利益,要压缩寻租的空间。这不是一个简单的过程,从中央政府一直到地方、到基层,要打通“最后一公里”。
11. Our gut bacteria are messing with us in ways we could never have imagined. New research has revealed that neurodegenerative diseases like Parkinson's might actually start out in the gut, rather than the brain, and there's mounting evidence that the human microbiome could be to blame for chronic fatigue syndrome. With gut bacteria showing signs of controlling our appetite, changing our brain structure, and triggering brain lesions that could lead to strokes, our tiny passengers are a force to be reckoned with.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

And others simply disappeared:
But at the end of a madcap Golden Globes (Ms. Fey toasted it as 'the beautiful mess we hoped it would be'), the major honors soberly ended up with the favorites. David O. Russell's con-artist caper 'American Hustle' led with three awards, including best film comedy. And despite missing out in the other six categories it was nominated in, the unflinching historical drama '12 Years a Slave' concluded the night as best film drama.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

中国国家统计局工业司何平在随后发布的数据解读声明中称,尽管石油和其他投入价格下跌支撑了利润率,但出厂价格的下跌抵消了这些利好影响。
楼下还有一间八边形的小房间,内有筒形穹顶天花板,几面玻璃墙和一条嵌壁式长凳座椅。这个房间配备了环绕立体声。三间卧室都在楼上,全都带有湖景。
The capital plans to move most of its municipal departments to the suburban district of Tongzhou in 2017, the Beijing Municipal Committee announced on Wednesday.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 部分消费贷或暗中涌向房地产市场
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

competition

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
From the themed collection: 四川10余陶企拟新建生产线扩产能
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

n. 繁荣,兴旺
6.《我爱你,菲利普·莫里斯》

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
From the themed collection: 今后5年广州供应住宅用地3225公顷
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Note that grosses are not the same thing as earnings. Downey outearned Johnson by $29 million with $75 million in estimated earnings between June 2012 and June 2013, the period we used for the latest edition of our Celebrity 100 list. The numbers we’re looking at here are how many dollars each star’s movies brought in at the box office worldwide this year.
Frustrated, he invented something that would allow him take a picture of himself: He called it the "extender stick." Since the iPhone really hadn't been invented yet, a small camera was to be attached to one end of the stick. It also had a small mirror in its front so that users could see how they would look in the photograph. He patented the "extender stick" in 1983. The product was mass produced for sale but it was a commercial failure. The quality of the pictures was low. Besides, previous research showed that the women back then were embarrassed by the idea of taking pictures of themselves. The selfie stick was then reinvented by Wayne Fromm in the year 2000, three years before Hiroshi's patent expired. Fromm called his the "quik pod." He believes he is the inventor of today's selfie sticks and has even sued several other selfie stick producers. When asked about Hiroshi's selfie sticks, he said they were "prior art."

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 张维出任北京市规划国土委主任
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

最近两年你都没有涨薪水
获奖者:金·卡戴珊

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

追踪制造业、服务业和建筑业商务活动的官方指标显示,10月份这几个驱动中国经济的关键行业的增长有所放缓。
添加方式1.扫描上方可可官方微信二维码。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Facebook CEO Mark Zuckerberg

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

This figure marks the highest rate of growth since 2011. As the total annual box office in China five years ago was only 10 billion yuan.
米拉·库尼斯继续在各种性感女星排行榜上占据一席之地。
时间:2011-12-28 编辑:Richard
2008年,中国政府增加了一个归类为精神疾病的条目:"网瘾症"。据大量官方媒体报道,中国的年轻人花太多时间泡在网吧里,不顾家人和工作玩网络游戏到凌晨,有时甚至不吃,不喝,不睡眠,严重危害了自己的健康。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

4) I often feel inhibited in social interactions 0 1 2 3 4

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

There’s no arguing with that one. From bathroom signs to fashion runways, the gender lines have been blurring at an ever-faster pace. It’s about time we ended ye olde pink/blue, girl/boy stereotype divide.
[smɑ:t]
With the right tools in place, you’ll find yourself more productive and efficient.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

'But then what I do is I nudge him with a little reference to a newspaper article he happens to glance at which just reminds him that these things will give him cancer.
《风流医生俏护士》首播时,鹰眼和诱捕者这两个角色原本同等重要,也正是在这样的条件下,韦恩·罗杰斯才同意扮演诱捕者约翰。然而,当艾伦·艾尔达开始对这个角色进行改动并对整个剧情走向产生更大影响时,鹰眼使诱捕者这一角色黯然失色。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Are you often irritable?
2. Don’t fantasize about big brother: I am only legend.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

“一个员工离开时留了张便利贴,上面写着他走人了。”

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

一份产业报告显示,随着国内手机制造商加快创新,国产品牌手机仍占据国内手机出货量的主要份额。
最近,无人驾驶汽车的新闻屡见报端,它也叫做自动驾驶汽车。谷歌的自动驾驶汽车是此行业的领头羊,已行驶48万千米(30万英里),仅发生过两次交通事故,还都是人为因素造成的。事实上,无人驾驶汽车并不是新奇事物,早在达·芬奇发明以弹簧发条作驱动带内置预设程序的马车时,自动驾驶的概念便名噪一时。
5.射击类比赛项目

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

tracks
科技:凯迪拉克将在汽车的后视镜添加高清视频功能,其视野要比传统的后视镜开扩四倍,因为它能够在最大程度上减少了车柱和乘客对视线的影响,对于上了年纪的凯迪拉克车主和颈椎不好的人来说,这的确是个福音。下一个即将被广泛采用的技术,则是让汽车在倒车时,能够发出像垃圾车那样的“滴滴声”。
不过,黄金比萨早就不是第一种加入了黄金的食物。“马尼拉社交俱乐部”是纽约威廉斯堡一家菲律宾餐厅,今年早些时候,餐厅老板Bj?rn DelaCruz制作了一款昂贵的黄金水晶宇部甜甜圈。
语言本是人们沟通的工具,没有性别之分,但由于男女的社会分工、性格特色、生理特点不同,每一种语言都深深地打上了性别的烙印。在国外,有部分社会语言学家,专门研究语言

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 瓷砖产品趋向风格多样化、个性化
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

今年最令人惊喜的消息还包括油价下跌。经济学家对油价下跌的经济影响也是见仁见智,一方面认为消费者因此节省了不少油钱,一方面则认为这种趋势会影响石油的开采钻探活动。但大家普遍认为这会影响小型车和混合动力车的销量。油价下跌加上车价过高,使得凯迪拉克公司的电动轿跑ELR稳居2014年最不受欢迎的车型“宝座”。11月份,这款售价高达8万美元的电动跑车只卖出了155辆。
The PPI fell 5.3 per cent year-on-year in January, moderating from December’s -5.9 per cent pace. PPI has remained in negative territory since March 2012, reaching a low of -5.9 per cent for the five consecutive months since August 2015.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

“我的Summly宣言是让尽可能多的用户在移动端用上我们的技术,”达洛伊西奥在谈到雅虎的数亿用户时表示,“鉴于雅虎以内容门户而闻名,我们将有机会从根本上改变内容消费方式。”
Zhang Jingxiu, executive director of Beijing-based employment consultancy Newjincin Research Institute, said he didn't monitor the significant decrease of students' willingness to start businesses, but he does admit the desire to found startups among students on campus is low.
这些包括纳米汽车在内的轻巧设计小得甚至连肉眼都不可见。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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Sometimes Anna’s hair, which is lighter than Ms. Chastain’s natural color, is pulled back, creating layers and a bit of playfulness, but still maintaining authority.
如果2017年是假新闻之年,那么2018年将成为假数据之年。就像假新闻以多种不同形式出现一样——既有被美国总统称为假新闻的真新闻,也有在社交媒体上吸引众多观众的无稽之谈——假数据也是如此。

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